In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes
نویسندگان
چکیده
منابع مشابه
Anti-hyperglycemic Activity of Four Plants Extracts Effective against Alpha Glucosidase in Normal and Diabetic Rats
Background & Aims: Postprandial hyperglycemia results in the development of chronic complications. Therefore, its control is critical in the treatment of diabetes. One of the main therapeutic approaches for reducing postprandial hyperglycemia is to reduce the absorption of carbohydrates by enzyme inhibitors such as Acarbose which have already been clinically used as a medicine for diabetic pati...
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Background: The mechanism of hypoglycemic and hypolipidemic activities of Pyrus biossieriana Buhse leaf extract (PbBLE) and its phytochemical component arbutin, have not been well determined. The present study was performed to understand the hypoglycemic activity mechanisms of pbBLE and arbutin more clearly.Methods: In vitro enzymatic carbohydrate digestion with PbBLE and arbutin was assessed u...
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The aim of this work was to evaluate the inhibitory activities of methanolic extracts of Artocarpus altilis, Cinnamomum zeylanicum, Piper betel and Artocarpus heterophyllus on Wheat alpha amylase and Baker’s yeast alpha glucosidase at varying concentrations. Diabetes mellitus is a clinical condition characterized by hyperglycaemia in which an elevated amount of glucose circulates in the blood p...
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Background: Diabetes mellitus is a group of metabolic disorders that are associated with elevated blood glucose levels due to impaired insulin secretion, insulin function, or both. alpha-glucosidase is a key enzyme in hydrolyzing carbohydrates and raising blood sugar levels. This study aimed to investigate the bioinformatics of inhibition of the alpha-glucosidase enzyme by the main constituent...
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ژورنال
عنوان ژورنال: Pharmacia
سال: 2020
ISSN: 2603-557X,0428-0296
DOI: 10.3897/pharmacia.67.e58392